Overall, audiences reacted positively to "Me, You & Luna," praising the acting, particularly Chinenye's natural performance. Viewers appreciated the film's blend of humor and relatable themes, such as workplace stress and the search for genuine connection. Some highlighted the realistic office setting and the unexpected role of the dog, Luna, in the narrative. Although many enjoyed the film's conclusion, there were calls for a sequel, with one viewer stating, "This shouldn’t be the end of this movie."